SPD304 dihydrochloride

Research use only, not for human use.

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 μM. SPD304 dihydrochloride promotes dissociation of TNF trimers.

SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 μM. SPD304 dihydrochloride promotes dissociation of TNF trimers.(In Vitro):The survivability of aHSCs is significantly rescued by SPD304 dihydrochloride (2 μM). The production of lipid hydroxides and intracellular GSH are increased as well. GA (75 μM) and SPD304 dihydrochloride (2 μM) downregulate TRADD (almost 2-fold) and p?RIP3 (1.4?fold) compared to GA and promote the activation of caspase 8.

SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p?RIP3 1.4?fold compared to GA alone, and promotes caspase 8 activation.

SPD304 cannot be used in vivo due to its high toxicity.

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Apoptosis

TNF

AP-1

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1049741-03-8

620.54

C32H34Cl2F3N3O2

>98% (HPLC)

In Vitro:?DMSO : 11.36 mg/mL (18.31 mM)

Cl.Cl.CN(CCN(C)Cc1coc2cc(C)c(C)cc2c1=O)Cc1cn(-c2cccc(c2)C(F)(F)F)c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years